How do brains wire themselves up?
Faculty
Paola Arlotta
Professor of Stem Cell and Regenerative Biology
Catherine Dulac
Samuel W. Morris University Professor
Takao Hensch
Professor of Molecular and Cellular Biology
Sam Kunes
Professor of Molecular and Cellular Biology
Margaret Livingstone
Takeda Professor of Neurobiology, HMS
Jeffrey Macklis
Max and Anne Wien Professor of Life Sciences, Harvard University
Leah Somerville
Professor of Psychology
News and Publications
- Rapid synaptic and gamma rhythm signature of mouse critical period plasticityQuast KB, Reh RK, Caiati MD, Kopell N, McCarthy MM, Hensch TK
Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2123182120. doi: 10.1073/pnas.2123182120… - Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex
Uzquiano A, Kedaigle AJ, Pigoni M, Paulsen B, Adiconis X, Kim K, Faits T, Nagaraja S, Antón-Bolaños N, Gerhardinger C, Tucewicz A, Murray E, Jin X, Buenrostro J, Chen F, Velasco S, Regev A, Levin JZ, Arlotta P.
Cell. 2022 Sep 29;185(20):3770-3788.e27. doi: 10.1016/j.cell.2022.09.010. PMID: 36179669
… - Pyramidal neuron subtype diversity governs microglia states in the neocortex
Jeffrey A. Stogsdill, Kwanho Kim, Loïc Binan, Samouil L. Farhi, Joshua Z. Levin & Paola Arlotta
Nature volume 608, pages 750–756 (2022)
… - Temporally divergent regulatory mechanisms govern neuronal diversification and maturation in the mouse and marmoset neocortex
Wen Yuan, Sai Ma, Juliana R. Brown, Kwanho Kim, Vanessa Murek, Lucia Trastulla, A. Meissner, S. Lodato, Ashwin S. Shetty, J. Levin, J. Buenrostro, M. Ziller, P. Arlotta
Nature Neuroscience volume 25, pages 1049–1058 (2022)
… - Tle4 controls both developmental acquisition and postnatal maintenance of corticothalamic projection neuron identity
M. Galazo, D. Sweetser, J. D. Macklis
… - Autism genes converge on asynchronous development of shared neuron classes
B. Paulsen, Silvia Velasco, …, P. Arlotta
Nature volume 602, pages 268–273 (2022)
… - Stretchable Mesh Nanoelectronics for 3D Single‐Cell Chronic Electrophysiology from Developing Brain OrganoidsP Le Floch, Q Li, Z Lin, S Zhao, R Liu, K Tasnim, H Jiang, J Liu
Advanced Materials 34 (11), 2106829….