The basal ganglia control the detailed kinematics of learned motor skills

July 15, 2021

The basal ganglia are known to influence action selection and modulation of movement vigor, but whether and how they contribute to specifying the kinematics of learned motor skills is not understood. Here, we probe this question by recording and manipulating basal ganglia activity in rats trained to generate complex task-specific movement patterns with rich kinematic structure. We find that the sensorimotor arm of the basal ganglia circuit is crucial for generating the detailed movement patterns underlying the acquired motor skills. Furthermore, the neural representations in the striatum, and the control function they subserve, do not depend on inputs from the motor cortex. Taken together, these results extend our understanding of the basal ganglia by showing that they can specify and control the fine-grained details of learned motor skills through their interactions with lower-level motor circuits.


Ashesh K Dhawale, Steffen B E Wolff, Raymond Ko, Bence P Ölveczky

Agent-based models reveal limits of mark-release-recapture estimates for the rare butterfly, Bhutanitis thaidina (Lepidoptera: Papilionidae)

July 14, 2021

Insect diversity and abundance are in drastic decline worldwide, but quantifying insect populations to better conserve them is a difficult task. Mark-release-recapture (MRR) is widely used as an ecological indicator for insect populations, but the accuracy of MRR estimates can vary with factors such as spatial scale, sampling effort and models of inference. We conducted a three-year MRR study of B. thaidina in Yanzigou valley, Mt. Gongga but failed to obtain sufficient data for a robust population estimate. This prompted us to integrate B. thaidina life history information to parameterize agent-based models and evaluate the conditions under which successful MRR studies could be conducted. We evaluated: (1) the performance of MRR models under different landscape types, and (2) the influence of experimental design on the accuracy and variance of MRR-based estimates. Our simulations revealed systematic underestimates of true population parameters by MRR models when sampling effort was insufficient. In a total of 2772 simulations, subjective decisions in sampling protocol (e.g. frequency, number of sampling locations, use of spatially explicit models, type of estimands) accounted for nearly half of the variation in estimates. We conclude that MRR-based estimates could be improved with the addition of more field-specific parameters. This article is protected by copyright. All rights reserved.

Zhengyang Wang, Yuanheng Li, Anuj Jain, Naomi E Pierce 

Causal inference gates corticostriatal learning

July 9, 2021

Attributing outcomes to your own actions or to external causes is essential for appropriately learning which actions lead to reward and which actions do not. Our previous work showed that this type of credit assignment is best explained by a Bayesian reinforcement learning model which posits that beliefs about the causal structure of the environment modulate reward prediction errors (RPEs) during action value updating. In this study, we investigated the brain networks underlying reinforcement learning that are influenced by causal beliefs using functional magnetic resonance imaging (fMRI) while human participants (n = 31; 13 males, 18 females) completed a behavioral task that manipulated beliefs about causal structure. We found evidence that RPEs modulated by causal beliefs are represented in dorsal striatum, while standard (unmodulated) RPEs are represented in ventral striatum. Further analyses revealed that beliefs about causal structure are represented in anterior insula and inferior frontal gyrus. Finally, structural equation modeling revealed effective connectivity from anterior insula to dorsal striatum. Together, these results are consistent with a possible neural architecture in which causal beliefs in anterior insula are integrated with prediction error signals in dorsal striatum to update action values.SIGNIFICANCE STATEMENT:Learning which actions lead to reward - a process known as reinforcement learning - is essential for survival. Inferring the causes of observed outcomes - a process known as causal inference - is crucial for appropriately assigning credit to one's own actions and restricting learning to effective action-outcome contingencies. Previous studies have linked reinforcement learning to the striatum and causal inference to prefrontal regions, yet how these neural processes interact to guide adaptive behavior remains poorly understood. Here, we found evidence that causal beliefs represented in the prefrontal cortex modulate action value updating in posterior striatum, separately from the unmodulated action value update in ventral striatum posited by standard reinforcement learning models.


Hayley M Dorfman, Momchil Tomov, Bernice Cheung, Dennis Clarke, Samuel J Gershman , Brent L Hughes 

Generating and Using Transcriptomically Based Retinal Cell Atlases

July 6, 2021

It has been known for over a century that the basic organization of the retina is conserved across vertebrates. It has been equally clear that retinal cells can be classified into numerous types, but only recently have methods been devised to explore this diversity in unbiased, scalable, and comprehensive ways. Advances in high-throughput single-cell RNA-sequencing (scRNA-seq) have played a pivotal role in this effort. In this article, we outline the experimental and computational components of scRNA-seq and review studies that have used them to generate retinal atlases of cell types in several vertebrate species. These atlases have enabled studies of retinal development, responses of retinal cells to injury, expression patterns of genes implicated in retinal disease, and the evolution of cell types. Recently, the inquiry has expanded to include the entire eye and visual centers in the brain. These studies have enhanced our understanding of retinal function and dysfunction and provided tools and insights for exploring neural diversity throughout the brain. Expected final online publication date for the Annual Review of Vision Science, Volume 7 is September 2021. Please see for revised estimates.


Karthik Shekhar Joshua R Sanes

On the evolution of a functional approach to memory

June 29, 2021

In an analysis of memory systems, Sherry and Schacter (Psychological Review, 94, 439-454, 1987) emphasized the importance of functional and evolutionary considerations for characterizing mechanisms of memory. The present article considers four different yet closely related topics from more recent research in which similar considerations have played a prominent role in shaping both experiment and theory: the seven sins of memory, mechanisms underlying memory misattribution errors, the role of memory in imagining future experiences, and the relation between associative inference and memory errors. These lines of research illustrate the usefulness of attempting to integrate functional and mechanistic considerations, in line with the general approach articulated by Sherry and Schacter.

Daniel L Schacter