In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes

Xin Jin , Sean K Simmons , Amy Guo, Ashwin S Shetty , Michelle Ko , Lan Nguyen , Vahbiz Jokhi , Elise Robinson , Paul Oyler , Nathan Curry , Giulio Deangeli , Simona Lodato , Joshua Z Levin , Aviv Regev , Feng Zhang , Paola Arlotta

A Unified Framework for Dopamine Signals across Timescales

HyungGoo R Kim , Athar N Malik, John G Mikhael, Pol Bech, Iku Tsutsui-Kimura, Fangmiao Sun , Yajun Zhang , Yulong Li , Mitsuko Watabe-Uchida , Samuel J Gershman , Naoshige Uchida

Young adult-born neurons improve odor coding by mitral cells.

Shani-Narkiss H, Vinograd A, Landau ID, Tasaka G, Yayon N, Terletsky S, Groysman M, Maor I, Sompolinsky H, Mizrahi A.

Dynamic content reactivation supports naturalistic autobiographical recall in humans

Adrian W Gilmore, Alina Quach, Sarah E Kalinowski, Stephen J Gotts, Daniel L Schacter, Alex Martin

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What We Do

Researchers in the Center for Brain Science (CBS) are discovering how brain circuits give rise to computations that underlie thought and behavior. We are determining the structure and function of neural circuits; investigating how these circuits govern behavior and vary between individuals; learning how they change during development and aging; and deepening our understanding of what is amiss in neurological and psychiatric disorders, and how to address these pathologies. To accomplish this mission, CBS brings neuroscientists together with physical scientists and engineers to develop and deploy new tools for neuroscience. Headquartered in the new Northwest Building on Oxford Street in Cambridge, CBS has strong links throughout the neuroscience community at Harvard University. Members are drawn from the Faculty of Arts and Sciences, the Harvard Medical School, the School of Engineering and Applied Sciences, and the Harvard-affiliated hospitals.

Neuroengineering: what tools we need

Neuroimaging: what underlies our thoughts

Light Microscopy: what the brain looks like 

Electron Microscopy: what is the brain's nanostructure

Connectome Project: how the brain is wired

Swartz Program: how do we understand brain function

Education: what training we need