The striatum specifies the statistics of behavior

Published Date: 
August 29, 2019

Markowitz JE, Datta SR

Taken together, new recording technologies and automated methods for annotating behavior allowed our group, and others, to show that individual SPNs contain a relational map of action, dSPNs and iSPNs encode action complementarily, and SPNs control how movements are organized sequentially over time. This work reveals a more general role for both dSPNs and iSPNs in the process of selecting which action to perform among dozens of possible actions on a moment-by-moment basis. Thus, clinically, pathologies of the BG may be manifest both in the form and kinematics of movements and in the statistics of how movements are deployed over time.