Reversing the flow: Cortical control over subcortical processing in the central auditory pathway


April 21, 2015 - 1:00pm
NW 243
About the Speaker
Dan Polley (MGH)

Anatomists have described a massive but specific projection system originating in layers 5 and 6 of the sensory neocortex that terminate throughout subcortical limbic, motor and sensory areas. Less is know about the functional contribution of these corticofugal projections to ongoing subcortical processing. I will present work that describes modulation of sensory response properties in the auditory and visual thalamus in the freely moving mouse by extra-sensory factors such as movement and behavioral task demands. I will then describe our recent successes (and failures) in identifying a role for corticofugal projections in thalamic and midbrain sound processing.