Encoding of action by the Purkinje cells of the cerebellum

Summary

Date: 
November 4, 2014 - 1:00pm
Location: 
NW 243
About the Speaker
Name: 
Reza Shadmehr (Johns Hopkins)

Execution of accurate eye movements depends critically on the cerebellum, as evidenced by the deficits observed in patients and lesion studies.  These observations have suggested that Purkinje cells (P-cells) predict the state of the eye (e.g., its speed or direction) during a saccade.  Yet, this encoding has remained a long-standing puzzle because P-cell firing shows little modulation with respect to saccade speed or direction.  Here, we analyzed P-cell discharge in the oculomotor vermis of behaving monkeys during saccades and estimated the inhibition that these cells produced at the caudal fastigial nucleus (cFN).  We uncovered a time course of synaptic input at cFN that precisely predicted the real-time speed of the eye.  When we aligned the simple spikes of each P-cell to a coordinate system that depended on that cell’s complex spike (CS) tuning, the result unmasked a pattern of inhibition at cFN that encoded both saccade speed and direction via a multiplicative coding, i.e., a gain-field.  Therefore, our results suggested two new principles regarding function and anatomy of the cerebellum: the encoding of state of the eye does not occur in the firing rates of individual P-cells, but via synchronized inputs to cFN; the anatomical projections of P-cells to cFN neurons are not random, but organized by the CS tuning properties of the P-cells.