Functional imaging multimodal circuit dynamics in the behaving rodent hippocampus


February 24, 2015 - 1:00pm
NW 243
About the Speaker
Attila Losonczy (Columbia)

The mammalian hippocampus has been inexorably linked to spatial navigation and episodic learning. These intricate hippocampal functions have been thought to emerge from elementary interactions among excitatory, inhibitory and neuromodulatory motifs in canonical microcircuits located in all areas of the hippocampus. We have started to dissect the roles of these different circuit motifs in hippocampal-dependent behaviors by using cellular-resolution functional population imaging in behaving mice. In my talk, I will first summarize our recent efforts with these methods to investigate the contribution of GABAergic inhibitory and neuromodulatory circuit elements to hippocampal-dependent episodic learning in vivo. I will also present results from our ongoing projects aimed at dissecting the contribution of developmentally-defined subpopulations of hippocampal principal neurons to behaviorally-relevant hippocampal network dynamics during spatial navigation and learning.