Modulation of pheromone sensitivity and courtship behavior by a reproductive hormone

Summary

Date: 
October 11, 2016 - 12:00pm - 1:00pm
Location: 
Northwest 243
About the Speaker
Name: 
Chih-Ying Su
Speaker Title: 
Asst Professor
Speaker Affiliation: 
UCSD

Abstract: During the lifespans of most animals, reproductive maturity and mating activity are highly coordinated. In Drosophila melanogaster, for instance, male fertility increases with age and older males are known to have a copulation advantage over young ones. The molecular and neural basis of this age-related disparity in mating behavior is unknown. By using genetic, functional and behavioral approaches, we show that the Or47b odorant receptor is required for the copulation advantage of older males. Notably, the sensitivity of Or47b neurons to a stimulatory pheromone, palmitoleic acid, is low in young males but high in older ones, which accounts for older males’ higher courtship intensity. Mechanistically, this age-related sensitization of Or47b neurons requires a reproductive hormone, juvenile hormone, as well as its binding protein Methoprene-tolerant in Or47b neurons. Together, our study identifies a direct neural substrate for juvenile hormone that permits coordination of courtship activity with reproductive maturity to maximize male reproductive fitness.