Ion channel control of dopamine-subtype selective activity in health and Parkinson disease


June 25, 2015 - 1:00pm
NW 243
About the Speaker
Jochen Roeper (Goethe University Frankfurt)

The patterned activity of dopamine midbain neurons is essential for key brain functions such as movement, motivation and cognition. Loss of cells and altered activity of dopamine neurons causes major brain disorders like schizophrenia or Parkinson disease. Based on the characterization of dopamine neuron diversity (Lammel et al. 2008 Neuron; Roeper 2013 TINS), we aim to understand the changes in ion channel function in selective subgroups of dopamine midbrain neurons in the context of Parkinson disease (Schiemann et al. 2012, Nature Neuroscience, Subramaniam et al. 2014, J. Neuroscience).