Illuminated algorithms: expanding recordings of the neural code in space, time, and specificity.


March 31, 2016 - 10:00am
Northwest 353
About the Speaker
Jesse Marshall (Stanford)

Neural codes are distributed among the complex fabric of cell types and nuclei of the mammalian nervous system. Conventional electrophysiological recording techniques have provided enormous insight into the role of neuronal firing patterns and oscillations in behavior and disease. However electrophysiological techniques are limited in their ability to localize oscillations to specific cell types and regions, and record firing activity densely in an unbiased, cell-type specific manner. I will discuss two stories detailing the development and application of new in vivo optical recording methodologies for deciphering neural signaling with unprecedented precision and breadth in space, time and specificity. First, I will detail the invention of a new technique, TEMPO, that I use to record cell-type specific neuronal oscillations in freely moving mice. Second, I will then detail two experiments applying cell-type specific calcium imaging to the D1- and D2-MSNs in the dorsal striatum in freely moving mice during normal behavior and the parkinsonian state.