Functional effects of distinct innervation styles of fast spiking cortical interneurons on pyramidal cells

Summary

Date: 
November 21, 2014 - 12:00pm
Location: 
NW 243
About the Speaker
Name: 
Yoshiyuki Kubota (National Institute for Physiological Sciences, Japan)

Inhibitory interneurons target precise membrane regions on pyramidal cells, but differences in their functional effects on somata, dendrites and spines remain unclear. We analyzed inhibitory synaptic events induced by cortical, fast-spiking (FS) basket cells which innervate dendritic shafts and spines as well as pyramidal cell somata. We find large somatic synapses are strong while smaller, dendritic synapses are weaker. Simulations with precise anatomical and physiological data reveal functional differences between different innervation styles. FS cell soma-targeting synapses initiate a strong, global inhibition, those on shafts inhibit more restricted dendritic zones, while synapses on spines may mediate a strictly local veto. Thus, FS cell synapses of different sizes and sites provide functionally diverse forms of pyramidal cell inhibition.