Dopaminergic memory modulation by two distinct novelty systems


December 14, 2017 - 1:30pm
Northwest Building Room 243
About the Speaker
Tomonori Takeuchi
Speaker Title: 
Senior Postdoctoral Research Fellow
Speaker Affiliation: 
The University of Edinburgh

Most everyday memories may form automatically in the hippocampus. The key role of this memory system is to filter our unnecessary information, but keep the important memories by a mechanism that involves novelty-associated dopamine release in the hippocampus. Recent our studies (Takeuchi et al., Nature, 2016) revealed that projections from neurons in the locus coeruleus to the hippocampus can drive the environmental novelty-associated enhancement of memory retention through non-canonical release of dopamine in the hippocampus. These studies also raise a possibility that the impact of environmental novelty may differ from that of reward-associated novelty, and projections from neurons in the ventral tegmental area to the hippocampus might mediate reward-associated novelty which modulates the memory retention with a narrow time window (Yamasaki and Takeuchi, Neural Plasticity, 2017).