Distinct pathways in the entopeduncular nucleus for limbic and sensorimotor output


May 24, 2017 - 1:00pm - 2:00pm
Northwest Building 243
About the Speaker
Mike Wallace
Speaker Title: 
Postdoctoral Fellow, Sabatini Lab
Speaker Affiliation: 
Harvard University

The basal ganglia
(BG) integrate inputs from diverse sensorimotor, limbic, and associative
regions to guide action-selection and goal-directed behaviors.  The
entopeduncular nucleus (EP) is a major BG output nucleus and has been suggested
to channel signals from distinct BG nuclei to target regions involved in
diverse functions. Here we use single-cell transcriptional and molecular
analyses to demonstrate that the EP contains at least three classes of
projection neurons–glutamate/GABA coreleasing somatostatin neurons,
glutamatergic parvalbumin neurons, and GABAergic parvalbumin neurons. 
These classes comprise functionally and anatomically distinct output pathways
that differentially affect EP-target regions such as the lateral habenula (LHb)
and thalamus.