Axon Degeneration: Molecular Mechanisms and Therapeutic Potential

Summary

Date: 
October 30, 2018 - 12:00pm
Location: 
BioLabs Building, Room 1080
About the Speaker
Name: 
Aaron DiAntonio
Speaker Title: 
Professor
Speaker Affiliation: 
Washington University

Axon degeneration is an early event contributing to morbidity and progression of neurodegenerative diseases including peripheral neuropathy, multiple sclerosis, ALS, and Parkinson’s disease. Axon degeneration is active program of subcellular destruction, akin to apoptosis but using a distinct molecular program. We have identified the essential molecular mechanisms driving axon loss in the injured and diseased nervous system, finding that local regulation of neurometabolism is the key driver of axonal self-destruction. We are using these new molecular insights to develop novel therapeutics for the prevention and treatment of neurological diseases characterized by axon loss.