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Shown is a two-photon image of neurons located in the visual cortex of transgenic mice expressing cyan fluorescent protein (CFP) and yellow fluorescent protein (YFP) in a small (<1 %) subset of neurons. Neurons and their processes (dendrites, dendritic spines, and axons) are clearly visible.
Image by Dr. Narayanan Kasthuri in the Center for Brain Science. Mouse produced by Feng et al., 2000 with Judy Tollett.
This image shows the brain of a triple transgenic mouse modified to express 3 fluorescent proteins in different subsets of neurons (cyan, yellow, and red fluorescent proteins). The center of the image displays the curved hippocampal formation, while the upper portion shows neurons in the cerebral cortex.
Image by Tamily Weissman in the Center for Brain Science. Mouse produced by Feng et al., 2000 with Judy Tollett.
Image taken from a Brainbow multicolor transgenic mouse, showing motor axons in a peripheral nerve expressing different levels of red, yellow and cyan fluorescent proteins. These mice have been genetically engineered so that each axon expresses a random combination of the three fluorescent proteins. Multiple axons can then be distinguished from each other by their specific color. By simultaneously tracing many interacting neurons in the same sample, we hope to get a better understanding of the ‘connectome’.
Image and mouse produced by Dr. Jean Livet in the Center for Brain Science.
